Preclinical testing of oncolytic adenovirus sensitivity in patient-derived tumor organoids

Summary: Patient-derived organoids (PDOs) have shown the potential to reflect patient sensitivity to chemotherapeutic or targeted drugs. Recently, we showed that organoid models can also serve as a platform to screen for selectivity and potency of oncolytic adenoviruses (OAds). In this protocol, we...

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Bibliographic Details
Main Authors: Silvia Pascual-Sabater, Giulia Raimondi, Ana Mato-Berciano, Eva C. Vaquero, Fabio Ausania, Cristina Fillat
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:STAR Protocols
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721007231