Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis

Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis

ABSTRACT Nontuberculous mycobacteria (NTM), including Mycobacterium avium, are clinically important pathogens in cystic fibrosis (CF). The innate immune response to M. avium remains incompletely understood. We evaluated the role of complement opsonization in neutrophil-mediated killing of M. avium....

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Bibliographic Details
Main Authors: Patricia M. Lenhart-Pendergrass, Kenneth C. Malcolm, Emily Wheeler, Noel M. Rysavy, Katie Poch, Silvia Caceres, Kara M. Calhoun, Stacey L. Martiniano, Jerry A. Nick
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium avium
nontuberculous mycobacteria
neutrophils
cystic fibrosis
opsonization
complement C3
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03279-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03279-22

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