Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus

Abstract Overexpression of NorA efflux pumps plays a pivotal role in the multidrug-resistance mechanism in S. aureus. Here, we investigated the activities of prenylated isoflavonoids, present in the legume plant family (Fabaceae), as natural efflux pump inhibitors (EPIs) in fluoroquinolone-resistant...

Full description

Bibliographic Details
Main Authors: Marina Ika Irianti, Jean-Paul Vincken, Sarah van Dinteren, Ellen ter Beest, Klaas Martinus Pos, Carla Araya-Cloutier
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48992-8