Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes

Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes

The thymus gland is a primary lymphoid organ for T-cell development. Various viral infections can result in disturbance of thymic functions. Medullary thymic epithelial cells (mTECs) are important for the negative selection of self-reactive T-cells to ensure central tolerance. Insulin-like growth fa...

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Bibliographic Details
Main Authors: Abdulaziz Alhazmi, Magloire Pandoua Nekoua, Hélène Michaux, Famara Sane, Aymen Halouani, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Martens, Hela Jaidane, Vincent Geenen, Didier Hober
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
viruses
enterovirus
Coxsackievirus B
thymus
self-tolerance
autoimmunity
Online Access:https://www.mdpi.com/2076-2607/9/6/1177

Internet

https://www.mdpi.com/2076-2607/9/6/1177

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