Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis

Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis

The terminal nucleotidyltransferases TUT4 and TUT7 (TUT4/7) regulate miRNA and mRNA stability by 3′ end uridylation. In humans, TUT4/7 polyuridylates both mRNA and pre-miRNA, leading to degradation by the U-specific exonuclease DIS3L2. We investigate the role of uridylation-dependent decay in mainta...

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Bibliographic Details
Main Authors: Pengcheng Zhang, Mallory I. Frederick, Ilka U. Heinemann
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
RNA degradation
uridylation dependent decay
microRNA homeostasis
transcriptome
miRNA/mRNA network
oncogenic signaling
Online Access:https://www.mdpi.com/2073-4409/11/23/3742

Internet

https://www.mdpi.com/2073-4409/11/23/3742

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