Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genetic polymorphisms and atopic asthma in children from Southeastern Brazil

Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genetic polymorphisms and atopic asthma in children from Southeastern Brazil

Xenobiotics can trigger degranulation of eosinophils and mast cells. In this process, the cells release several substances leading to bronchial hyperactivity, the main feature of atopic asthma (AA). GSTM1 and GSTT1 genes encode enzymes involved in the inactivation of these compounds. Both genes are...

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Bibliographic Details
Main Authors: Carmen Silvia Passos Lima, Iramaia Angélica Néri, Gustavo Jacob Lourenço, Isabel Cristina Jacinto Faria, José Dirceu Ribeiro, Carmen Silvia Bertuzzo
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2010-01-01
Series:Genetics and Molecular Biology
Subjects:
Atopic asthma
pathogenesis
GSTM1 gene
GSTT1 gene
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300007

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