Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms

Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms

AimSignal transducer and activator of transcription (STAT) signaling is critical for the pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated STAT3 (PIAS3) negatively modulates STAT3 activity, but its role in AAA disease remains undefined.MethodAAAs were induced i...

Full description

Bibliographic Details
Main Authors: Weilai Fu, Haole Liu, Panpan Wei, Congcong Xia, Qingqing Yu, Kangli Tian, Yankui Li, Enqi Liu, Baohui Xu, Masaaki Miyata, Rong Wang, Sihai Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
abdominal aortic aneurysm
protein inhibitor of activated STAT3
inflammation
macrophage
animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1092555/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1092555/full

Similar Items