Sex‐Specific Differences in Gsα‐Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone

Sex‐Specific Differences in Gsα‐Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone

ABSTRACT Teriparatide, recombinant parathyroid hormone (PTH[1‐34]), and abaloparatide, an analogue of PTH related‐peptide (PTHrP[1‐34]), are both anabolic medications for osteoporosis that target the PTH receptor PTH1R. PTH1R is a G protein–coupled receptor, and the stimulatory Gs protein is an impo...

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Bibliographic Details
Main Authors: Srilatha Swami, Joshua Johnson, Lawrence A Vecchi, Matthew J Kim, Beate Lanske, Rachelle W Johnson, Joy Y Wu
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:JBMR Plus
Subjects:
ANABOLICS
GENETIC ANIMAL MODELS
OSTEOBLASTS
OSTEOPOROSIS
PTH/VIT D/FGF23
Online Access:https://doi.org/10.1002/jbm4.10695

Internet

https://doi.org/10.1002/jbm4.10695

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