Multi-omics computational analysis unveils the involvement of AP-1 and CTCF in hysteresis of chromatin states during macrophage polarization

Multi-omics computational analysis unveils the involvement of AP-1 and CTCF in hysteresis of chromatin states during macrophage polarization

Macrophages display extreme plasticity, and the mechanisms and applications of polarization and de-/repolarization of macrophages have been extensively investigated. However, the regulation of macrophage hysteresis after de-/repolarization remains unclear. In this study, by using a large-scale compu...

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Bibliographic Details
Main Authors: Yubo Zhang, Wenbo Yang, Yutaro Kumagai, Martin Loza, Weihang Zhang, Sung-Joon Park, Kenta Nakai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
macrophages
macrophage hysteresis
repolarization
M1 macrophage
M2 macrophage
polarization memory
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1304778/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1304778/full

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