Acute, subchronic toxicity and genotoxicity studies of JointAlive, a traditional Chinese medicine formulation for knee osteoarthritis.

<h4>Aim</h4>In vivo and in vitro toxicity tests of JointAlive® were studied in animal models to support the safe use of JointAlive® as a drug for knee osteoarthritis treatment.<h4>Methods</h4>The acute toxicity study in Sprague Dawley (SD) rats was conducted at a 20 g/kg bw/d...

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Bibliographic Details
Main Authors: Yuanyuan Wang, Li Li, Yanling Mu, Shanglong Wang, Xin Li, Jiancheng Zong, Shengcan Zou, Zimin Liu, Dehai Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292937&type=printable