Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.

Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.

BACKGROUND: Patients with inherited dilated cardiomyopathy (DCM) frequently die with severe heart failure (HF) or die suddenly with arrhythmias, although these symptoms are not always observed at birth. It remains unclear how and when HF and arrhythmogenic changes develop in these DCM mutation carri...

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Bibliographic Details
Main Authors: Takeshi Suzuki, Takao Shioya, Takashi Murayama, Masami Sugihara, Fuminori Odagiri, Yuji Nakazato, Hiroto Nishizawa, Akihito Chugun, Takashi Sakurai, Hiroyuki Daida, Sachio Morimoto, Nagomi Kurebayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3325934?pdf=render

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http://europepmc.org/articles/PMC3325934?pdf=render

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