Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-<i>b</i>-ε-caprolactone) Micelles

Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-<i>b</i>-ε-caprolactone) Micelles

Polymeric micelles are promising carriers for the delivery of poorly water-soluble drugs, providing enhanced drug solubility, blood circulation times, and bioavailability. Nevertheless, the storage and long-term stability of micelles in solution present challenges requiring the lyophilization and st...

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Bibliographic Details
Main Authors: Md. Saddam Hussain, Khandokar Sadique Faisal, Andrew J. Clulow, Hugo Albrecht, Marta Krasowska, Anton Blencowe
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Polymers
Subjects:
micelles
lyophilization
cryoprotection
reconstitution
redispersibility
β-CD
Online Access:https://www.mdpi.com/2073-4360/15/8/1974

Internet

https://www.mdpi.com/2073-4360/15/8/1974

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