Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression

Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression

Abstract Background and aims The therapeutic efficacy of single-dose mesenchymal stromal cell (MSC) therapy for heart failure (HF) remains inconsistent. This study aimed to investigate whether infusion with two-dose human umbilical cord MSC (hUCMSCs) could be therapeutically superior to single-dose...

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Bibliographic Details
Main Authors: Chenyi Gong, Lei Chang, Xuan Sun, Yu Qi, Rong Huang, Ke Chen, Bin Wang, Lina Kang, Lian Wang, Biao Xu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Stem Cell Research & Therapy
Subjects:
Human umbilical cord mesenchymal stem cells
Rat dilated cardiomyopathy
Myocardial inflammation
Indoleamine 2,3-dioxygenase
Regulatory T cells
Online Access:https://doi.org/10.1186/s13287-022-03101-w

Internet

https://doi.org/10.1186/s13287-022-03101-w

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