Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis

Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that demonstrates a dramatically increasing incidence worldwide. This study provides novel insights into the capacity of the exogenous β-hydroxybutyrate and ketogenic diet (KD) consumption to alleviate dextran...

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Bibliographic Details
Main Authors: Rasha Abdelhady, Sameh Saber, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S. Alamri, Jaber Alfaifi, Masoud I. E. Adam, Lobna A. Saleh, Azza I. Farag, Elsayed A. Elmorsy, Hend S. El-Wakeel, Ahmed S. Doghish, Mohamed E. Shaker, Sara H. Hazem, Heba A. Ramadan, Rabab S. Hamad, Osama A. Mohammed
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
β-hydroxybutyrate
NLRP3 inflammasome
apoptosis
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1239025/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1239025/full

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