Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells

Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells

Streptococcus pneumoniae (S. pn), the bacterial pathogen responsible for invasive pneumococcal diseases, is capable of producing substantial amounts of hydrogen peroxide. However, the impact of S. pn-secreted hydrogen peroxide (H2O2) on the host immune processes is not completely understood. Here, w...

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Bibliographic Details
Main Authors: Yue Gao, Wenchun Xu, Xiaoyun Dou, Hong Wang, Xuemei Zhang, Shenghui Yang, Hongyi Liao, Xuexue Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
Streptococcus pneumoniae
hydrogen peroxide
mitochondrial damage
mtDNA
IFNβ
STING
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00630/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00630/full

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