A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids

A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids

Background and Aims: Drug-induced liver injury (DILI) is a major failure mode in pharmaceutical development. This study aims to address the limitations of existing preclinical models by assessing a high-throughput, microfluidic liver-on-a-chip system, termed “Curio Barrier Liver Chips,” and its capa...

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Bibliographic Details
Main Authors: Sophia R. Meyer, Charles J. Zhang, Max A. Garcia, Megan C. Procario, Sanghee Yoo, Amber L. Jolly, Sumin Kim, Jiho Kim, Kyusuk Baek, Roland D. Kersten, Robert J. Fontana, Jonathan Z. Sexton
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Gastro Hep Advances
Subjects:
Drug-Induced Liver Injury
Hepatotoxicity
Microfluidic Liver Chips
Microphysiologic Liver System
High-Throughput Screening
iPSC-Derived Human Liver organoids
Online Access:http://www.sciencedirect.com/science/article/pii/S2772572324001183

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http://www.sciencedirect.com/science/article/pii/S2772572324001183

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