Signal processing in the TGF-beta superfamily ligand-receptor network.
The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell growth, apoptosis, and differentiation. We use computational...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC1356091?pdf=render |
| _version_ | 1828304731695480832 |
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| author | Jose M G Vilar Ronald Jansen Chris Sander |
| author_facet | Jose M G Vilar Ronald Jansen Chris Sander |
| author_sort | Jose M G Vilar |
| collection | DOAJ |
| description | The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell growth, apoptosis, and differentiation. We use computational modeling to show that coupling of signaling with receptor trafficking results in a highly versatile signal-processing unit, able to sense by itself absolute levels of ligand, temporal changes in ligand concentration, and ratios of multiple ligands. This coupling controls whether the response of the receptor module is transient or permanent and whether or not different signaling channels behave independently of each other. Our computational approach unifies seemingly disparate experimental observations and suggests specific changes in receptor trafficking patterns that can lead to phenotypes that favor tumor progression. |
| first_indexed | 2024-04-13T14:16:25Z |
| format | Article |
| id | doaj.art-963f6c482b694bf4971f644433520373 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-13T14:16:25Z |
| publishDate | 2006-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-963f6c482b694bf4971f6444335203732022-12-22T02:43:38ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582006-01-0121e310.1371/journal.pcbi.0020003Signal processing in the TGF-beta superfamily ligand-receptor network.Jose M G VilarRonald JansenChris SanderThe TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell growth, apoptosis, and differentiation. We use computational modeling to show that coupling of signaling with receptor trafficking results in a highly versatile signal-processing unit, able to sense by itself absolute levels of ligand, temporal changes in ligand concentration, and ratios of multiple ligands. This coupling controls whether the response of the receptor module is transient or permanent and whether or not different signaling channels behave independently of each other. Our computational approach unifies seemingly disparate experimental observations and suggests specific changes in receptor trafficking patterns that can lead to phenotypes that favor tumor progression.http://europepmc.org/articles/PMC1356091?pdf=render |
| spellingShingle | Jose M G Vilar Ronald Jansen Chris Sander Signal processing in the TGF-beta superfamily ligand-receptor network. PLoS Computational Biology |
| title | Signal processing in the TGF-beta superfamily ligand-receptor network. |
| title_full | Signal processing in the TGF-beta superfamily ligand-receptor network. |
| title_fullStr | Signal processing in the TGF-beta superfamily ligand-receptor network. |
| title_full_unstemmed | Signal processing in the TGF-beta superfamily ligand-receptor network. |
| title_short | Signal processing in the TGF-beta superfamily ligand-receptor network. |
| title_sort | signal processing in the tgf beta superfamily ligand receptor network |
| url | http://europepmc.org/articles/PMC1356091?pdf=render |
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