Structural Insight of KSIII (β-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin

Structural Insight of KSIII (β-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin

Chlorothricin (CHL) belongs to a spirotetronate antibiotic family produced by <i>Streptomyces antibioticus</i> that inhibits pyruvate carboxylase and malate dehydrogenase. For the biosynthesis of CHL, ChlB3 plays a crucial role by introducing the 6-methylsalicylic acid (6MSA) moiety to C...

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Bibliographic Details
Main Authors: Asad Ullah Saeed, Mueed Ur Rahman, Hai-Feng Chen, Jianting Zheng
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
acyltransferase
ChlB3
hydrolysis
catalytic efficiency
structural insight
Online Access:https://www.mdpi.com/1420-3049/27/19/6405

Internet

https://www.mdpi.com/1420-3049/27/19/6405

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