Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol

Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol

Neuroinflammation, a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders, is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express higher levels of Ch25h, an enzyme that hydroxylates choles...

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Bibliographic Details
Main Authors: Anil G. Cashikar, Danira Toral-Rios, David Timm, Johnathan Romero, Michael Strickland, Justin M. Long, Xianlin Han, David M. Holtzman, Steven M. Paul
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Lipid Research
Subjects:
neuroinflammation
microglia
astrocyte
apolipoprotein E
Alzheimer disease
oxysterols
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000238

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http://www.sciencedirect.com/science/article/pii/S0022227523000238

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