Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood

DNA methylation at cytosine-phosphate-guanine (CpG) dinucleotides changes as a function of age in humans and animal models, a process that may contribute to chronic disease development. Recent studies have investigated the role of an oxidized form of DNA methylation – 5-hydroxymethylcytosine (5hmC)...

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Bibliographic Details
Main Authors: Joseph Kochmanski, Elizabeth H. Marchlewicz, Raymond G. Cavalcante, Maureen A. Sartor, Dana C. Dolinoy
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Epigenetics
Subjects:
Online Access:http://dx.doi.org/10.1080/15592294.2018.1507198