Substantially Delayed Maturation of Growth Plate Chondrocytes in “Humanized” PTH1R Mice with the H223R Mutation of Jansen's Disease

Substantially Delayed Maturation of Growth Plate Chondrocytes in “Humanized” PTH1R Mice with the H223R Mutation of Jansen's Disease

Abstract Activating parathyroid hormone (PTH)/PTH‐related Peptide (PTHrP) receptor (PTH1R) mutations causes Jansen's metaphyseal chondrodysplasia (JMC), a rare disease characterized by growth plate abnormalities, short stature, and PTH‐independent hypercalcemia. Previously generated transgenic...

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Bibliographic Details
Main Authors: Monica Reyes, Damla Firat, Patrick Hanna, Mohd Khan, Michael Bruce, Maria Shvedova, Tatsuya Kobayashi, Ernestina Schipani, Thomas J. Gardella, Harald Jüppner
Format: Article
Language:English
Published: Oxford University Press 2023-10-01
Series:JBMR Plus
Subjects:
ANIMAL MODELS
BIOCHEMICAL MARKERS OF BONE TURNOVER
BONE MODELING AND REMODELING
CELL/TISSUE SIGNALING – ENDOCRINE PATHWAYS
CHONDROCYTE AND CARTILAGE BIOLOGY
GENETIC ANIMAL MODELS
Online Access:https://doi.org/10.1002/jbm4.10802

Internet

https://doi.org/10.1002/jbm4.10802

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