Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo

Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo

ABSTRACT Hepatitis D is the most severe form of human viral hepatitis and currently lacks an efficient therapy. Dendritic cell-derived exosomes (Dexs) have been found to induce immune responses capable of eliminating viruses. However, the therapeutic potential of antigen-loaded exosomes in hepatitis...

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Bibliographic Details
Main Authors: Ting Yao, Mengjiao Lv, Siyuan Ma, Jinmei Chen, Yi Zhang, Yongsheng Yu, Guoqing Zang, Xiaohua Chen
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
HDV
dendritic cell-derived exosomes
ubiquitination
specific immune response
JAK/STAT pathway
hepatitis
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.01024-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.01024-21

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