Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Nicotinamide adenine dinucleotide (NAD) is a substrate of adenosine diphosphate (ADP)-ribosyl cyclase and is catalyzed to cyclic ADP-ribose (cADPR) by CD38 and/or CD157. cADPR, a Ca2+ mobilizing second messenger, is critical in releasing oxytocin from the hypothalamus into the brain. Although NAD pr...

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Bibliographic Details
Main Authors: Maria Gerasimenko, Haruhiro Higashida
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
NAD
nicotinamide riboside
CD157
CD38
social behavior
neuromodulator
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1166609/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1166609/full

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