Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca2+ signal in myotonic dystrophy type 1 myotubes

Resveratrol corrects aberrant splicing of RYR1 pre-mRNA and Ca2+ signal in myotonic dystrophy type 1 myotubes

Myotonic dystrophy type 1 (DM1) is a spliceopathy related to the mis-splicing of several genes caused by sequestration of nuclear transcriptional RNA-binding factors from non-coding CUG repeats of DMPK pre-mRNAs. Dysregulation of ryanodine receptor 1 (RYR1), sarcoplasmatic/endoplasmatic Ca2+-ATPase...

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Bibliographic Details
Main Authors: Massimo Santoro, Roberto Piacentini, Alessia Perna, Eugenia Pisano, Anna Severino, Anna Modoni, Claudio Grassi, Gabriella Silvestri
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
alternative splicing; calcium homeostasis; cug-bp1; foci; mbnl1; myotonic dystrophy type 1; myotubes; resveratrol
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=9;spage=1757;epage=1766;aulast=Santoro

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=9;spage=1757;epage=1766;aulast=Santoro

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