Palmitate-Induced Cell Death and Mitochondrial Respiratory Dysfunction in Myoblasts are Not Prevented by Mitochondria-Targeted Antioxidants

Palmitate-Induced Cell Death and Mitochondrial Respiratory Dysfunction in Myoblasts are Not Prevented by Mitochondria-Targeted Antioxidants

Background/Aims: Deleterious effects of saturated fatty acids in skeletal muscle cells are well known but their impact on mitochondrial respiration has not been well studied. Mitochondrial oxidative damage has been implicated to play a role in their effect. The purpose of this study was to evaluate...

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Bibliographic Details
Main Authors: Jana Patková, Michal Anděl, Jan Trnka
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Palmitate
Mitochondrial respiration
mtDNA integrity
Mitochondria-targeted antioxidants
MitoQ
MitoTEMPOL
Skeletal muscle
Myoblasts
Myotubes
Spare respiratory capacity
Online Access:http://www.karger.com/Article/FullText/358709

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http://www.karger.com/Article/FullText/358709

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