Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis.

Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis.

Pancreatic fibrosis, a prominent histopathological feature of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma, is essentially a dynamic process that leads to irreversible scarring of parenchymal tissues of the pancreas. Though the exact mechanisms of its initiation and development are...

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Bibliographic Details
Main Authors: Siu Wai Tsang, Hongjie Zhang, Chengyuan Lin, Haitao Xiao, Michael Wong, Hongcai Shang, Zhi-Jun Yang, Aiping Lu, Ken Kin-Lam Yung, Zhaoxiang Bian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3849497?pdf=render

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http://europepmc.org/articles/PMC3849497?pdf=render

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