C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

Abstract Background Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in platelet activation and regulates se...

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Bibliographic Details
Main Authors: Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras, Carmen Guerrero
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cell Communication and Signaling
Subjects:
C3G
Megakaryopoiesis
Megakaryocyte
Platelet
Differentiation
Online Access:http://link.springer.com/article/10.1186/s12964-018-0311-5

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http://link.springer.com/article/10.1186/s12964-018-0311-5

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