Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

Although hepatoprotective properties of silybin are well documented, the clinical therapeutic efficacy is limited by its low bioavailability due to absorption rates, extensive phase II metabolism, and biliary excretion. As our previous study indicated that metabolic enzymes may have limited effects...

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Bibliographic Details
Main Authors: Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
ABCC2 (MRP2)
ABCG2 (BCRP)
baicalein
silybin
pharmacokinetics
liver injury
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01115/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01115/full

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