Trifluoromethylated Flavonoid-Based Isoxazoles as Antidiabetic and Anti-Obesity Agents: Synthesis, In Vitro <i>α</i>-Amylase Inhibitory Activity, Molecular Docking and Structure–Activity Relationship Analysis

Trifluoromethylated Flavonoid-Based Isoxazoles as Antidiabetic and Anti-Obesity Agents: Synthesis, In Vitro <i>α</i>-Amylase Inhibitory Activity, Molecular Docking and Structure–Activity Relationship Analysis

Diabetes mellitus is a major health problem globally. The management of carbohydrate digestion provides an alternative treatment. Flavonoids constitute the largest group of polyphenolic compounds, produced by plants widely consumed as food and/or used for therapeutic purposes. As such, isoxazoles ha...

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Bibliographic Details
Main Authors: Faisal K. Algethami, Ilyes Saidi, Hani Nasser Abdelhamid, Mohamed R. Elamin, Babiker Y. Abdulkhair, Amani Chrouda, Hichem Ben Jannet
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
<i>α</i>-amylase inhibition
antidiabetic
anti-obesity
cycloaddition
flavonoids
trifluoromethylated flavonoid-based isoxazoles
Online Access:https://www.mdpi.com/1420-3049/26/17/5214

Internet

https://www.mdpi.com/1420-3049/26/17/5214

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