Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo

Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo

Abstract Background The activation of CD8+ T cells and their trafficking to the skin through JAK-STAT signaling play a central role in the development of vitiligo. Thus, targeting this key disease pathway with innovative drugs is an effective strategy for treating vitiligo. Natural products isolated...

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Bibliographic Details
Main Authors: Yuqian Chang, Pan Kang, Tingting Cui, Weinan Guo, Weigang Zhang, Pengran Du, Xiuli Yi, Sen Guo, Tianwen Gao, Chunying Li, Shuli Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Demethylzeylasteral
Vitiligo
CD8+ T cell
Keratinocytes
JAK
STAT
Online Access:https://doi.org/10.1186/s12967-023-04293-2

Internet

https://doi.org/10.1186/s12967-023-04293-2

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