Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death

Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death

Glutamine, like glucose, is a major nutrient consumed by cancer cells, yet these cells undergo glutamine starvation in the cores of tumors, forcing them to evolve adaptive metabolic responses. Pharmacologically targeting glutamine metabolism or withdrawal has been exploited for therapeutic purposes,...

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Bibliographic Details
Main Authors: Wen-Jun Liu, Peng-yu Pan, Ye Sun, Jian-bo Wang, Huan Zhou, Xin Xie, Zhi-yuan Duan, Han-yu Dong, Wen-na Chen, Li-de Zhang, Chun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
NSCLC
cisplatin resistance
glutamine deprivation
metabolic reprogramming
deferoxamine
cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.794735/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.794735/full

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