Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis

Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis

Future treatments of multiple sclerosis (MS), a chronic autoimmune neurodegenerative disease of the central nervous system (CNS), aim for simultaneous early targeting of peripheral immune function and neuroinflammation. Sphingosine-1-phosphate (S1P) receptor modulators are among the most promising d...

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Bibliographic Details
Main Authors: Alessandra Musella, Antonietta Gentile, Livia Guadalupi, Francesca Romana Rizzo, Francesca De Vito, Diego Fresegna, Antonio Bruno, Ettore Dolcetti, Valentina Vanni, Laura Vitiello, Silvia Bullitta, Krizia Sanna, Silvia Caioli, Sara Balletta, Monica Nencini, Fabio Buttari, Mario Stampanoni Bassi, Diego Centonze, Georgia Mandolesi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
sphingosine-1-phosphate receptors
glutamate synaptic dysfunction
microglia
T lymphocytes
experimental autoimmune encephalomyelitis (EAE)
pro-inflammatory cytokines
Online Access:https://www.mdpi.com/2073-4409/9/5/1290

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https://www.mdpi.com/2073-4409/9/5/1290

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