Co-Expression of Runx1, Hoxa9, Hlf, and Hoxa7 Confers Multi-Lineage Potential on Hematopoietic Progenitors Derived From Pluripotent Stem Cells

Co-Expression of Runx1, Hoxa9, Hlf, and Hoxa7 Confers Multi-Lineage Potential on Hematopoietic Progenitors Derived From Pluripotent Stem Cells

The intrinsic factors that determine the fundamental traits of engraftment ability and multi-lineage potential of hematopoietic stem cells (HSCs) remain elusive. The induction of bona fade HSCs from pluripotent stem cells (PSCs) in dishes is urgently demanded but remains a great challenge in transla...

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Bibliographic Details
Main Authors: Bo Yu, Bingyan Wu, Pingshan Hong, Huan Peng, Mengyun Zhang, Qi Zhang, Lijuan Liu, Xiaofei Liu, Yang Geng, Jinyong Wang, Yu Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Runx1
Hoxa9
Hlf
Hoxa7
pluripotent stem cells
transcription factors
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.859769/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.859769/full

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