Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment

Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment

Glioblastoma (GBM) is an aggressive primary central nervous system neoplasia with limited therapeutic options and poor prognosis. Following reports of cytomegalovirus (HCMV) in GBM tumors, the anti-viral drug Valganciclovir was administered and found to significantly increase the longevity of GBM pa...

Full description

Bibliographic Details
Main Authors: Mark A. A. Harrison, Emily M. Hochreiner, Brooke P. Benjamin, Sean E. Lawler, Kevin J. Zwezdaryk
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
human cytomegalovirus (HCMV)
glioblastoma (GBM)
metabolism
aerobic glycolysis
oxidative phosphorylation (OXPHOS)
lactate
Online Access:https://www.mdpi.com/1999-4915/14/1/103

Internet

https://www.mdpi.com/1999-4915/14/1/103

Similar Items