Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4‐Human Leukocyte Antigen‐DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension

Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4‐Human Leukocyte Antigen‐DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension

Background Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism (SNP) rs2856830, located near the human leukocyte antigen DPA1 (HLA‐DPA1) gene. We aimed to define the genetic architecture of functional va...

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Bibliographic Details
Main Authors: Neha Hafeez, Anna Kirillova, Yunshan Yue, Rashmi J. Rao, Neil J. Kelly, Wadih El Khoury, Yassmin Al Aaraj, Yi‐Yin Tai, Adam Handen, Ying Tang, Danli Jiang, Ting Wu, Yingze Zhang, Dennis McNamara, Tatiana V. Kudryashova, Elena A. Goncharova, Dmitry Goncharov, Thomas Bertero, Mehdi Nouraie, Gang Li, Wei Sun, Stephen Y. Chan
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial dysfunction
genome‐wide association study
linkage disequilibrium
pulmonary arterial hypertension
single nucleotide polymorphism
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.027894

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https://www.ahajournals.org/doi/10.1161/JAHA.122.027894

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