Stimulation of Hepatic Ferritinophagy Mitigates <i>Irp2</i> Depletion-Induced Anemia

Stimulation of Hepatic Ferritinophagy Mitigates <i>Irp2</i> Depletion-Induced Anemia

Background: Iron regulatory proteins (IRPs) maintain cellular iron homeostasis. Due to aberrant tissue-iron distribution, <i>Irp2</i>-deficient mice suffer microcytic anemia and neurodegeneration, while iron overload occurs in the liver and intestine. We previously found that <i>Ir...

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Bibliographic Details
Main Authors: Yutong Liu, Yuxuan Li, Liu Yang, Jiaqi Shen, Hongting Zhao, Weichen Dong, Yanzhong Chang, Tong Qiao, Kuanyu Li
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
IRP2
Hif2 inhibition
Fe-S clusters
ferritinophagy
microcytic anemia
Online Access:https://www.mdpi.com/2076-3921/12/3/566

Internet

https://www.mdpi.com/2076-3921/12/3/566

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