Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics

Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics

ABSTRACT Previous work suggests that altered lipid metabolism may be associated with daptomycin resistance in Gram-positive pathogens, but lipidomic changes underlying resistance are not fully understood. We performed untargeted lipidomics by using three-dimensional hydrophilic interaction liquid ch...

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Bibliographic Details
Main Authors: Kelly M. Hines, Adam Waalkes, Kelsi Penewit, Elizabeth A. Holmes, Stephen J. Salipante, Brian J. Werth, Libin Xu
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mSphere
Subjects:
PgsA
antibiotic resistance
daptomycin
Gram-positive bacteria
ion mobility-mass spectrometry
lipidomics
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00492-17

Internet

https://journals.asm.org/doi/10.1128/mSphere.00492-17

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