Intravascular Ketamine Increases Theta-Burst but Not High Frequency Tetanus Induced LTP at CA3-CA1 Synapses Within Three Hours and Devoid of an Increase in Spine Density

Intravascular Ketamine Increases Theta-Burst but Not High Frequency Tetanus Induced LTP at CA3-CA1 Synapses Within Three Hours and Devoid of an Increase in Spine Density

In the past 20 years, ketamine has become a promising treatment for Major Depressive Disorder (MDD) due to its rapid and sustain antidepressant effects in patients. A single ketamine treatment causes improvement in depressive symptoms within hours and can last weeks, long after it is eliminated. Pre...

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Bibliographic Details
Main Authors: Allie J. Widman, Amy E. Stewart, Elise M. Erb, Elizabeth Gardner, Lori L. McMahon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
hippocampus
anti-depressants
ketamine
synaptic plasticity
spine density
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00008/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2018.00008/full

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