GPIbα is the driving force of hepatic thrombopoietin generation

GPIbα is the driving force of hepatic thrombopoietin generation

Abstract Thrombopoietin (TPO), a glycoprotein hormone produced predominantly in the liver, plays important roles in the hematopoietic stem cell (HSC) niche, and is essential for megakaryopoiesis and platelet generation. Long‐standing understanding proposes that TPO is constitutively produced by hepa...

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Bibliographic Details
Main Authors: Danielle Karakas, Miao Xu, Heyu Ni
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
Platelet
GPIbα and GPIIbIIIa
Thrombopoietin
Thrombocytopenia
Thrombosis
Antibodies
Online Access:https://doi.org/10.1002/rth2.12506

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