Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation

Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation

JAK3 is principally activated by members of the interleukin-2 receptor family and plays an essential role in lymphoid development, with inactivating JAK3 mutations causing autosomal-recessive severe combined immunodeficiency (SCID). This study aimed to generate an equivalent zebrafish model of SCID...

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Bibliographic Details
Main Authors: Faiza Basheer, Effie Lee, Clifford Liongue, Alister C. Ward
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
JAK3
immunodeficiency
SCID
lymphoid cells
leukemia
zebrafish
Online Access:https://www.mdpi.com/2218-273X/12/10/1521

Internet

https://www.mdpi.com/2218-273X/12/10/1521

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