Metabolic engineering of Acremonium chrysogenum for improving cephalosporin C production independent of methionine stimulation

Metabolic engineering of Acremonium chrysogenum for improving cephalosporin C production independent of methionine stimulation

Abstract Background Cephalosporin C (CPC) produced by Acremonium chrysogenum is one of the most important drugs for treatment of bacterial infectious diseases. As the major stimulant, methionine is widely used in the industrial production of CPC. In this study, we found methionine stimulated CPC pro...

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Bibliographic Details
Main Authors: Jiajia Liu, Wenyan Gao, Yuanyuan Pan, Gang Liu
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Microbial Cell Factories
Subjects:
Acremonium chrysogenum
Acppm1
AcsamS
Cephalosporin C (CPC)
mecB
Metabolic engineering
Online Access:http://link.springer.com/article/10.1186/s12934-018-0936-5

Internet

http://link.springer.com/article/10.1186/s12934-018-0936-5

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