JMJD6 orchestrates a transcriptional program in favor of endocrine resistance in ER+ breast cancer cells

JMJD6 orchestrates a transcriptional program in favor of endocrine resistance in ER+ breast cancer cells

High expression of Jumonji domain containing protein 6 (JMJD6) is strongly associated with poor prognosis in estrogen receptor positive (ER+) breast cancer. We overexpressed JMJD6 in MCF7 cells (JOE cells) and performed RNA-seq analysis. 76% of differentially expressed genes (DEGs) overlapped with E...

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Bibliographic Details
Main Authors: Partha Das, Aritra Gupta, Kartiki V. Desai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
estrogen receptor
RET
Tamoxifen
RNA-seq
MAPK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1028616/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1028616/full

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