Synthesis, Biological, Spectroscopic and Computational Investigations of Novel <i>N</i>-Acylhydrazone Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Dual COX/LOX Inhibitors

Synthesis, Biological, Spectroscopic and Computational Investigations of Novel <i>N</i>-Acylhydrazone Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Dual COX/LOX Inhibitors

Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-<...

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Bibliographic Details
Main Authors: Jakub Mikus, Piotr Świątek, Patrycja Przybyła, Edward Krzyżak, Aleksandra Marciniak, Aleksadra Kotynia, Aleksandra Redzicka, Benita Wiatrak, Paulina Jawień, Tomasz Gębarowski, Łukasz Szczukowski
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
AAG
ADME
cyclooxygenase
fluorescence spectroscopy
HSA
inflammation
Online Access:https://www.mdpi.com/1420-3049/28/14/5479

Internet

https://www.mdpi.com/1420-3049/28/14/5479

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