Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy

Abstract Studies of mouse models of Alzheimer's disease (AD) have demonstrated that nitric oxide synthase 2 (NOS2) is involved in AD pathology. However, the effects of NOS2 on the pathology of Parkinson’s disease (PD) are not well studied. To address this gap, we examined the impact of NOS2 on...

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Bibliographic Details
Main Authors: Jieun Kim, Jung-Youn Han, Yujeong Lee, Kipom Kim, Young Pyo Choi, Sehyun Chae, Hyang-Sook Hoe
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Brain
Subjects:
Online Access:https://doi.org/10.1186/s13041-023-00996-1