Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice

Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice

Oxytocin (OT), a hormone synthesized within the paraventricular nucleus and supraoptic nucleus of the hypothalamus, when given intracerebroventricularly, induces strong scratching behaviors. However, it is not clear whether intradermal injection (ID) of OT elicits itch sensation. Herein, we found th...

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Bibliographic Details
Main Authors: Rulong Li, Hua Sun, Haotian Zheng, Zhihua Zong, Shengnan Li, Tingting Meng, Jing Li, Yunfang Liu, Chao Wang, Jingxin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
oxytocin
itch
vasopressin-1a receptor
chloroquine
nitric oxide
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01380/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01380/full

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