Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.

Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.

Presence of tubulointerstitial fibrosis is predictive of progressive decline in kidney function, independent of its underlying cause. Injury to the renal microvasculature is a major factor in the progression of fibrosis and identification of factors that regulate endothelium in fibrosis is desirable...

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Bibliographic Details
Main Authors: Krishnapriya Loganathan, Ebtisam Salem Said, Emily Winterrowd, Martina Orebrand, Liqun He, Michael Vanlandewijck, Christer Betsholtz, Susan E Quaggin, Marie Jeansson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5749705?pdf=render

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http://europepmc.org/articles/PMC5749705?pdf=render

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