Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes

In mouse cardiomyocytes, the expression of two subfamilies of the calcium/calmodulin-regulated cyclic nucleotide phosphodiesterase 1 (PDE1)—PDE1A and PDE1C—has been reported. PDE1C was found to be the major subfamily in the human heart. It is a dual substrate PDE and can hydrolyze both 3′,5′-cyclic...

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Main Authors: Nadja I. Bork, Hariharan Subramanian, Roberta Kurelic, Viacheslav O. Nikolaev, Sergei D. Rybalkin
Format: Article
Jezik:English
Izdano: MDPI AG 2023-12-01
Serija:Cells
Teme:
Online dostop:https://www.mdpi.com/2073-4409/12/23/2759