Keratoconus: A biomechanical perspective on loss of corneal stiffness
Keratoconus (KC) is progressive disease of corneal thinning, steepening and collagen degradation. Biomechanics of the cornea is maintained by the intricate collagen network, which is responsible for its unique shape and function. With the disruption of this collagen network, the cornea loses its sha...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=8;spage=392;epage=393;aulast=Roy |
| _version_ | 1811202241940422656 |
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| author | Abhijit Sinha Roy Rohit Shetty Mathew Kurian Kummelil |
| author_facet | Abhijit Sinha Roy Rohit Shetty Mathew Kurian Kummelil |
| author_sort | Abhijit Sinha Roy |
| collection | DOAJ |
| description | Keratoconus (KC) is progressive disease of corneal thinning, steepening and collagen degradation. Biomechanics of the cornea is maintained by the intricate collagen network, which is responsible for its unique shape and function. With the disruption of this collagen network, the cornea loses its shape and function, resulting in progressive visual degradation. While KC is essentially a stromal disease, there is evidence that the epithelium undergoes significant thinning similar to the stroma. Several topographical approaches have been developed to detect KC early. However, it is now hypothesized that biomechanical destabilization of the cornea may precede topographic evidence of KC. Biomechanics of KC has been investigated only to a limited extent due to lack of in vivo measurement techniques and/or devices. In this review, we focus on recent work performed to characterize the biomechanical characteristics of KC. |
| first_indexed | 2024-04-12T02:36:32Z |
| format | Article |
| id | doaj.art-9682ce6e06db4b69a75e1f5f430b4ba0 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-12T02:36:32Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-9682ce6e06db4b69a75e1f5f430b4ba02022-12-22T03:51:33ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892013-01-0161839239310.4103/0301-4738.116057Keratoconus: A biomechanical perspective on loss of corneal stiffnessAbhijit Sinha RoyRohit ShettyMathew Kurian KummelilKeratoconus (KC) is progressive disease of corneal thinning, steepening and collagen degradation. Biomechanics of the cornea is maintained by the intricate collagen network, which is responsible for its unique shape and function. With the disruption of this collagen network, the cornea loses its shape and function, resulting in progressive visual degradation. While KC is essentially a stromal disease, there is evidence that the epithelium undergoes significant thinning similar to the stroma. Several topographical approaches have been developed to detect KC early. However, it is now hypothesized that biomechanical destabilization of the cornea may precede topographic evidence of KC. Biomechanics of KC has been investigated only to a limited extent due to lack of in vivo measurement techniques and/or devices. In this review, we focus on recent work performed to characterize the biomechanical characteristics of KC.http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=8;spage=392;epage=393;aulast=RoyEpidemiologykeratoconusprevalenceDisease pathogenesisgenetic heterogeneitygenetics and genomicsgenome-wide association studygenomic locikeratoconuslinkage mappingmolecular mechanismswhole exome-genome sequencingDeregulationectasiagene expressionkeratoconusmass spectroscopyproteomicssignaling pathwaysCorneacrosslinkingkeratoconusmodulus |
| spellingShingle | Abhijit Sinha Roy Rohit Shetty Mathew Kurian Kummelil Keratoconus: A biomechanical perspective on loss of corneal stiffness Indian Journal of Ophthalmology Epidemiology keratoconus prevalence Disease pathogenesis genetic heterogeneity genetics and genomics genome-wide association study genomic loci keratoconus linkage mapping molecular mechanisms whole exome-genome sequencing Deregulation ectasia gene expression keratoconus mass spectroscopy proteomics signaling pathways Cornea crosslinking keratoconus modulus |
| title | Keratoconus: A biomechanical perspective on loss of corneal stiffness |
| title_full | Keratoconus: A biomechanical perspective on loss of corneal stiffness |
| title_fullStr | Keratoconus: A biomechanical perspective on loss of corneal stiffness |
| title_full_unstemmed | Keratoconus: A biomechanical perspective on loss of corneal stiffness |
| title_short | Keratoconus: A biomechanical perspective on loss of corneal stiffness |
| title_sort | keratoconus a biomechanical perspective on loss of corneal stiffness |
| topic | Epidemiology keratoconus prevalence Disease pathogenesis genetic heterogeneity genetics and genomics genome-wide association study genomic loci keratoconus linkage mapping molecular mechanisms whole exome-genome sequencing Deregulation ectasia gene expression keratoconus mass spectroscopy proteomics signaling pathways Cornea crosslinking keratoconus modulus |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=8;spage=392;epage=393;aulast=Roy |
| work_keys_str_mv | AT abhijitsinharoy keratoconusabiomechanicalperspectiveonlossofcornealstiffness AT rohitshetty keratoconusabiomechanicalperspectiveonlossofcornealstiffness AT mathewkuriankummelil keratoconusabiomechanicalperspectiveonlossofcornealstiffness |