SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses

SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses

Background: Upon SARS-CoV-2 infection, most individuals develop neutralizing antibodies and T-cell immunity. However, some individuals reportedly remain SARS-CoV-2 PCR positive by pharyngeal swabs weeks after recovery. Whether viral RNA in these persistent carriers is contagious and stimulates SARS-...

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Bibliographic Details
Main Authors: Line K. Vibholm, Stine S.F. Nielsen, Marie H. Pahus, Giacomo S. Frattari, Rikke Olesen, Rebecca Andersen, Ida Monrad, Anna H.F. Andersen, Michelle M. Thomsen, Christina V. Konrad, Sidsel D. Andersen, Jesper F. Højen, Jesper D. Gunst, Lars Østergaard, Ole S. Søgaard, Mariane H. Schleimann, Martin Tolstrup
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
Persistent PCR positive
Immunology
Antibodies
CD8 T cell responses
Transmission
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000232

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421000232

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