D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription

D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription

CREB-regulated transcription coactivator 1 (CRTC1), a pivotal synaptonuclear messenger, regulates synaptic plasticity and transmission to prevent depression. Despite exhaustive investigations into CRTC1 mRNA reductions in the depressed mice, the regulatory mechanisms governing its transcription rema...

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Bibliographic Details
Main Authors: Yaxin Guo, Nuo Chen, Ming Zhao, Baihui Cao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Yan Li, Lining Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Pharmacological Research
Subjects:
Major depressive disorder
D-arabinose
CRTC1
PPARγ
TFEB
ACSS2
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182400080X

Internet

http://www.sciencedirect.com/science/article/pii/S104366182400080X

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